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At Memorial Sloan Kettering (MSK), we're not only changing the way we treat cancer, but also the way the world thinks about it. By working together and pushing forward with innovation and discovery, we're driving excellence and improving outcomes. We're treating cancer, one patient at a time. Join us and make a difference every day.

In compliance with applicable New York and New Jersey State regulatory authorities, COVID-19 vaccination (2 doses of either the Pfizer or Moderna vaccine or one dose of the Johnson & Johnson vaccine) is mandatory for all MSK employees, contingent workers, and volunteers. Exceptions are permitted for those employees who request and receive an approved medical or fully remote exemption.

*Staff working at a MSK New Jersey location must be up to date with COVID-19 vaccination, which includes having completed the primary COVID-19 vaccination series and booster once eligible as mandated by New Jersey State. All New Jersey staff not yet eligible for a booster must receive a booster within 3 weeks of becoming eligible as a condition of continued employment at MSK.

Note: Individuals are eligible to receive a COVID-19 booster five months after receiving the second dose of either the Pfizer or Moderna vaccine or two months after the J&J vaccine.

Job Description

Post-doctoral researcher position available in the van den Brink Lab

Research Area: Generation and evaluation of CAR T cells engineered to treat multiple myeloma.

The van den Brink lab at Memorial Sloan Kettering Cancer Center is looking for a highly motivated post-doc to work on a project involving novel T cell immunotherapies for multiple myeloma. Our lab focuses on a variety of research topics related to cancer immunotherapy, including hematopoietic stem cell transplantation, graft-versus-host disease, effects of the microbiota on transplant outcomes, immune reconstitution/thymic rejuvenation strategies, and CAR T cell therapy for various malignancies.

The CAR T cell group of the van den Brink lab designs novel CAR T cells targeting hematologic malignancies with the goal of improving T cell activity while reducing toxicities. We study CAR T cell activity in syngeneic mouse models and are currently developing xenograft mouse models. This postdoc position will focus on developing next-generationCAR T cells targeting human myeloma antigens with the goal of translating these CAR T cells into clinical application.

Lab Website: https://www.mskcc.org/research/ski/labs/marcel-van-den-brink

Responsibilities:* human T cell cultures and viral transduction* in vitro cell proliferation, protein expression, cell viability, immunophenotyping, and cytoxicity assays* CRISPR/Cas9 and gene transfer* Generation and maintenance of tumor cell lines and virus producing-packaging lines in culture* Xenograft models of human myeloma in mice* Mouse handling, injection, and harvesting tissues* Multi-color flow cytometry* Molecular cloning of CAR constructs

Qualifications:* PhD, MD/PhD, or MD completed in cancer immunology, immunotherapy, T cell biology, cell engineering, or related field* Excellent verbal and written communication skills* Solid publication record* Experience will mammalian cell culture and aseptic techniques is essential* Experience with retroviral/lentiviral human T cell transduction methods is preferred* Experience with multi-color flow cytometry panels is preferred* Experience with mouse handling and procedures is advantageous, but not required

Accommodation:The van den Brink lab is located in the Mortimer B. Zuckerman Research Center of the Sloan Kettering Institute of MSKCC.It is part of the Immunology Program. MSKCC combines laboratories with a focus on basic as well as cancer research. MSKCC is located in a vibrant hub of world-renowned biomedical research institutions in New York's Upper East Side,adjacent to Rockefeller University and the Weill Cornell Medical College. The vast resources within MSKCC and thesesurrounding institutions will help to facilitate the success of the applicant's projects and enable to establish collaborationswith other laboratories.Salary is competitive and commensurate with experience. MSKCC offers dedicated housing for postdoctoral fellows. Thisis a 2-year appointment with possibility of renewal for up to 5 years based upon satisfactory job performance, continuingavailability of funds, and ongoing operational needs.

To apply:Applicants should submit their CV, a letter outlining interest and motivations and names and contact information of threereferences.

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MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision.

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